Dave Grohl

Dave Grohl and Foo Fighters have been drifting further and further into the mainstream over their 15-year existence, but their latest single and video, "Wheels," culled from their upcoming Greatest Hits package, is their most straightforward salvo yet. Watch the video below.

The song, which leaked last week, feels far more Kings of Leon than Queens of the Stone Age. Its midtempo strumming brings to mind some of the brawnier stuff coming out of Nashville these days.

It also has the nostalgic feel of a band looking back on a remarkable career that included a rise from the ashes of one of rock'n'roll's most iconic bands. "When the wheels touch ground, and you feel like it's all over," Grohl sings, "there's another round for you." Here's hoping that's true for Foo Fighters.

Greatest Hits arrives Nov. 3, and will also feature a second new song, "Word Forward."

And if you're craving heavier rocking from the Foos camp, catch Dave Grohl in the thumping power trio Them Crooked Vultures, and bassist Nate Mendel in the reunited Sunny Day Real Estate.